Reaction Details | |||
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Target | Bromodomain-containing protein 3 [326-398] | ||
Ligand | BDBM50092323 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | FP Competitive Binding Assay (No.350) | ||
Temperature | 298.15±n/a K | ||
Ki | 26±1.80 nM | ||
Comments | extracted | ||
Citation | Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bromodomain-containing protein 3 [326-398] | |||
Name: | Bromodomain-containing protein 3 [326-398] | ||
Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)(BD2) | Bromodomain-containing protein 3 Bromo 2 domain(BRD3 BD2) | KIAA0043 | RING3L | ||
Type: | n/a | ||
Mol. Mass.: | 8553.07 | ||
Organism: | Homo sapiens (Human) | ||
Description: | BD2 (326-398 aa) of Q15059 | ||
Residue: | 73 | ||
Sequence: |
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BDBM50092323 | |||
n/a | |||
Name | BDBM50092323 | ||
Synonyms: | CHEMBL3581656 | US9675697, Cpd. No. 21 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H21N5O2 | ||
Mol. Mass. | 387.4344 | ||
SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)n[nH]c3C)c21 |(5.34,2.95,;5.34,1.67,;3.96,.87,;2.62,1.63,;1.3,.87,;1.3,-.64,;2.62,-1.4,;3.96,-.64,;5.34,-1.44,;5.49,-3.01,;4.53,-3.86,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.03,.46,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.66,3.22,;-1.38,4.15,;-.17,3.76,;-1.89,5.66,;-3.48,5.64,;-3.96,4.12,;-5.16,3.71,;-1.3,.87,)| | ||
Structure |