| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
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| Ligand | BDBM179833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LSD1 Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 50±n/a nM |
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| Comments | extracted |
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| Citation |  Fyfe, MC; Ortega Muñoz, A; Castro-Palomino Laria, J; Martinell Pedemonte, M; Estiarte-Martinez, M; Valls Vidal, N Cyclopropylamine derivatives useful as LSD1 inhibitors US Patent US9676701 Publication Date 6/13/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A |
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| Name: | Lysine-specific histone demethylase 1A |
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| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 92901.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60341 |
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| Residue: | 852 |
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| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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| BDBM179833 |
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| n/a |
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| Name | BDBM179833 |
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| Synonyms: | US9676701, 68 N-(4′-((trans)-2-aminocyclopropyl)biphenyl-3-yl)benzenesulfonamide hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2O2S |
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| Mol. Mass. | 364.461 |
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| SMILES | N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)c2ccccc2)c1 |r| |
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| Structure | 
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