| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM9460 |
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| Substrate/Competitor | BDBM8592 |
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| Meas. Tech. | CYP19 Assay |
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| pH | 7±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 1410±10 nM |
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| IC50 | 2800±n/a nM |
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| Km | 90±10 nM |
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| Citation |  Su, B; Hackett, JC; Diaz-Cruz, ES; Kim, YW; Brueggemeier, RW Lead optimization of 7-benzyloxy 2-(4'-pyridylmethyl)thio isoflavone aromatase inhibitors. Bioorg Med Chem13:6571-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
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| Type: | Enzyme |
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| Mol. Mass.: | 57888.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11511 |
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| Residue: | 503 |
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| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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| BDBM9460 |
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| BDBM8592 |
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| Name | BDBM9460 |
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| Synonyms: | 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione | Aminoglutethimide AG, 4 | CHEMBL488 | Cytadren | EN300-53368 | Elipten | aminoglutethimide (AG) |
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| Type | Small organic molecule |
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| Emp. Form. | C13H16N2O2 |
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| Mol. Mass. | 232.2783 |
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| SMILES | CCC1(CCC(=O)NC1=O)c1ccc(N)cc1 |
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| Structure | 
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