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TargetDimer of Gag-Pol polyprotein [501-599]
LigandBDBM10153
Substrate/CompetitorFluorogenic Peptide Substrate
Meas. Tech.Protease Inhibition Assay
Ki 0.56±n/a nM
IC50 0.5±n/a nM
Citation Stranix, BRLavallee, JFSevigny, GYelle, JPerron, VLeBerre, NHerbart, DWu, JJ Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids. Bioorg Med Chem Lett16:3459-62 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [501-599]
Name:Dimer of Gag-Pol polyprotein [501-599]
Synonyms:HIV-1 Protease | HIV-1 Protease, recombinant, isolate HXB2
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [501-599]
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:P03367[501-599]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [501-599]
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:P03367[501-599]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM10153
Fluorogenic Peptide Substrate
Name:Fluorogenic Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:4156.59
Organism:n/a
Description:n/a
Residue:39
Sequence:
DABCYL-gamma-Abu-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS