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TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155]
LigandBDBM10228
Substrate/Competitorpoly rC/biotin-dG15
Meas. Tech.HIV-1 RT Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 27±n/a nM
Citation Yoakim, CBonneau, PRDeziel, RDoyon, LDuan, JGuse, ILandry, SMalenfant, ENaud, JOgilvie, WWO'Meara, JAPlante, RSimoneau, BThavonekham, BBos, MCordingley, MG Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives. Bioorg Med Chem Lett14:739-42 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Gag-Pol polyprotein [600-1027,R876K]/[600-1155]
Name:Gag-Pol polyprotein [600-1027,R876K]/[600-1155]
Synonyms:EC: 2.7.7.49 | HIV-1 Reverse Transcriptase
Type:Protein Complex
Mol. Mass.:113858
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [600-1155]
Synonyms:HIV-1 Reverse Transcriptase Chain A | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:63928.81
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1155]
Residue:556
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
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Component 2
Name:Gag-Pol polyprotein [600-1027,R876K]
Synonyms:HIV-1 Reverse Transcriptase Chain B | POL_HV1B1 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:49968.63
Organism:Human immunodeficiency virus type 1
Description:P03366[600-1027,R876K]
Residue:428
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
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BDBM10228
poly rC/biotin-dG15
Name:poly rC/biotin-dG15
Synonyms:n/a
Type:RNA-DNA duplex
Mol. Mass.:358.43
Organism:n/a
Description:The incorporation of Tritium-labeled [3H]dGTP onto a (poly)rC:(biotin)dG template:primer.
Residue:3
Sequence:
n/a