Reaction Details |
| Report a problem with these data |
Target | Gag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C] |
---|
Ligand | BDBM10228 |
---|
Substrate/Competitor | poly rC/biotin-dG15 |
---|
Meas. Tech. | HIV-1 RT Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 310±n/a nM |
---|
Citation | Yoakim, C; Bonneau, PR; Deziel, R; Doyon, L; Duan, J; Guse, I; Landry, S; Malenfant, E; Naud, J; Ogilvie, WW; O'Meara, JA; Plante, R; Simoneau, B; Thavonekham, B; Bos, M; Cordingley, MG Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives. Bioorg Med Chem Lett14:739-42 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Gag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C] |
---|
Name: | Gag-Pol polyprotein [600-1027,K702N,Y780C]/[600-1155,K702N,Y780C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N/Y181C) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [600-1155,K702N,Y780C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N/Y181C) Chain A | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 63853.70 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1155,K702N,Y780C] |
Residue: | 556 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
|
|
|
Component 2 |
Name: | Gag-Pol polyprotein [600-1027,K702N,Y780C] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N/Y181C) Chain B | POL_HV1B1 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 49893.53 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03366[600-1027,K702N,Y780C] |
Residue: | 428 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
|
|
|
BDBM10228 |
---|
poly rC/biotin-dG15 |
---|
Name: | poly rC/biotin-dG15 |
Synonyms: | n/a |
Type: | RNA-DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | The incorporation of Tritium-labeled [3H]dGTP onto a (poly)rC:(biotin)dG template:primer. |
Residue: | 3 |
Sequence: | |