| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-2 |
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| Ligand | BDBM10278 |
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| Substrate/Competitor | Caspase Substrate |
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| Meas. Tech. | Caspase Inhibition Assay |
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| IC50 | 530±n/a nM |
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| Citation |  Chen, YH; Zhang, YH; Zhang, HJ; Liu, DZ; Gu, M; Li, JY; Wu, F; Zhu, XZ; Li, J; Nan, FJ Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem49:1613-23 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Caspase-2 |
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| Name: | Caspase-2 |
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| Synonyms: | CASP-2 | CASP2 | CASP2_HUMAN | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | ICH1 | NEDD-2 | NEDD2 | Neural precursor cell expressed developmentally down-regulated protein 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50688.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42575 |
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| Residue: | 452 |
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| Sequence: | MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
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| BDBM10278 |
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| Caspase Substrate |
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| Name: | Caspase Substrate |
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| Synonyms: | n/a |
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| Type: | n/a |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 3 |
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| Sequence: | |
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