| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-2 |
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| Ligand | BDBM10305 |
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| Substrate/Competitor | Caspase-2 Fluorogenic Substrate |
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| Meas. Tech. | Caspase Inhibition Assay |
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| Ki | >25000±n/a nM |
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| Citation |  Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem44:2015-26 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Caspase-2 |
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| Name: | Caspase-2 |
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| Synonyms: | CASP-2 | CASP2 | CASP2_HUMAN | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | ICH1 | NEDD-2 | NEDD2 | Neural precursor cell expressed developmentally down-regulated protein 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 50688.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42575 |
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| Residue: | 452 |
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| Sequence: | MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
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| BDBM10305 |
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| Caspase-2 Fluorogenic Substrate |
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| Name: | Caspase-2 Fluorogenic Substrate |
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| Synonyms: | Ac-VDVAD-AMC |
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| Type: | n/a |
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| Mol. Mass.: | 1830.24 |
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| Organism: | n/a |
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| Description: | AMC=7-Amino-4-methylcoumarin |
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| Residue: | 20 |
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| Sequence: | Ac-Val-Asp-Val-Ala-Asp-AMC
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