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TargetCaspase-4
LigandBDBM10309
Substrate/CompetitorCaspase-4 Fluorogenic Substrate
Meas. Tech.Caspase Inhibition Assay
Ki>50000±n/a nM
Citation Lee, DLong, SAMurray, JHAdams, JLNuttall, MENadeau, DPKikly, KWinkler, JDSung, CMRyan, MDLevy, MAKeller, PMDeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem44:2015-26 (2001) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Caspase-4
Name:Caspase-4
Synonyms:CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease
Type:Enzyme
Mol. Mass.:43257.75
Organism:Homo sapiens (Human)
Description:P49662
Residue:377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS
MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE
RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT
ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN
RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF
IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP
TIERLSMTRYFYLFPGN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM10309
Caspase-4 Fluorogenic Substrate
Name:Caspase-4 Fluorogenic Substrate
Synonyms:Ac-LEED-AMC
Type:n/a
Mol. Mass.:1334.60
Organism:n/a
Description:AMC=7-Amino-4-methylcoumarin
Residue:14
Sequence:
Ac-Leu-Glu-Glu-Asp-AMC