| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-7 |
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| Ligand | BDBM10318 |
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| Substrate/Competitor | Caspase Fluorogenic Substrate |
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| Meas. Tech. | Caspase Inhibition Assay |
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| Ki | 47±n/a nM |
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| Citation |  Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem44:2015-26 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Caspase-7 |
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| Name: | Caspase-7 |
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| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 34273.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55210 |
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| Residue: | 303 |
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| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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| BDBM10318 |
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| Caspase Fluorogenic Substrate |
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| Name: | Caspase Fluorogenic Substrate |
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| Synonyms: | Ac-DEVD-AMC | Caspase Fluorogenic Substrate |
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| Type: | Peptide |
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| Mol. Mass.: | 1461.77 |
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| Organism: | n/a |
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| Description: | AMC=7-Amino-4-methylcoumarin |
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| Residue: | 16 |
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| Sequence: | |
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