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TargetCaspase-8
LigandBDBM10298
Substrate/CompetitorCaspase-8 Fluorogenic Substrate
Meas. Tech.Caspase Inhibition Assay
Ki 31000±n/a nM
Citation Lee, DLong, SAMurray, JHAdams, JLNuttall, MENadeau, DPKikly, KWinkler, JDSung, CMRyan, MDLevy, MAKeller, PMDeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem44:2015-26 (2001) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Caspase-8
Name:Caspase-8
Synonyms:Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog
Type:Enzyme
Mol. Mass.:55373.89
Organism:Homo sapiens (Human)
Description:Q14790
Residue:479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM10298
Caspase-8 Fluorogenic Substrate
Name:Caspase-8 Fluorogenic Substrate
Synonyms:Ac-IETD-AMC
Type:Peptide
Mol. Mass.:1673.49
Organism:n/a
Description:AMC=7-Amino-4-methylcoumarin
Residue:16
Sequence:
Ac-Ile-Glu-Thr-Asp-AMC