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TargetSphingosine-1-phosphate lyase 1
LigandBDBM313177
Substrate/Competitorn/a
Meas. Tech.S1P1 Binding Assay
IC50 5.20±n/a nM
Citation Dyckman AJDhar TGXiao HGilmore JLYang MGXiao ZMarcoux D Substituted bicyclic compounds US Patent  US10166249 Publication Date 1/1/2019
More Info.:Get all data from this article,  Assay Method
 
Sphingosine-1-phosphate lyase 1
Name:Sphingosine-1-phosphate lyase 1
Synonyms:KIAA1252 | S1PL | SGPL1 | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL
Type:PROTEIN
Mol. Mass.:63546.76
Organism:Homo sapiens (Human)
Description:ChEMBL_108363
Residue:568
Sequence:
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
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  Blast E-value cutoff:
BDBM313177
n/a
NameBDBM313177
Synonyms:US10166249, Example 693
TypeSmall organic molecule
Emp. Form.C25H34NO5P
Mol. Mass.459.5149
SMILESCOc1cccc(CCC2CCc3cc(ccc3C2)[C@H]2CC[C@](N)(COP(O)(O)=O)C2)c1 |r|
Structure
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