| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine-1-phosphate lyase 1 |
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| Ligand | BDBM65096 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | S1P1 Binding Assay |
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| IC50 | <10±n/a nM |
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| Citation |  Dyckman, AJ; Dhar, TG; Xiao, H; Gilmore, JL; Yang, MG; Xiao, Z; Marcoux, D Substituted bicyclic compounds US Patent US10166249 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine-1-phosphate lyase 1 |
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| Name: | Sphingosine-1-phosphate lyase 1 |
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| Synonyms: | KIAA1252 | S1PL | SGPL1 | SGPL1_HUMAN | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63546.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108363 |
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| Residue: | 568 |
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| Sequence: | MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
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| BDBM65096 |
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| n/a |
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| Name | BDBM65096 |
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| Synonyms: | US10166249, Example 461 | US9522888, 461 |
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| Type | n/a |
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| Emp. Form. | C23H36NO5P |
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| Mol. Mass. | 437.5094 |
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| SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#8]-[#6]-[#6@@H]-1-[#6]-[#6]-c2cc(ccc2-[#6]-1)-[#6@H]-1-[#6]-[#6][C@]([#7])([#6]-[#8]P([#8])([#8])=O)[#6]-1 |r| |
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| Structure | 
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