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TargetSphingosine-1-phosphate lyase 1
LigandBDBM313347
Substrate/Competitorn/a
Meas. Tech.S1P1 Binding Assay
IC50<10±n/a nM
Citation Dyckman, AJDhar, TGXiao, HGilmore, JLYang, MGXiao, ZMarcoux, D Substituted bicyclic compounds US Patent US10166249 Publication Date 1/1/2019
More Info.:Get all data from this article,  Assay Method
 
Sphingosine-1-phosphate lyase 1
Name:Sphingosine-1-phosphate lyase 1
Synonyms:KIAA1252 | S1PL | SGPL1 | SGPL1_HUMAN | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL
Type:PROTEIN
Mol. Mass.:63546.76
Organism:Homo sapiens (Human)
Description:ChEMBL_108363
Residue:568
Sequence:
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM313347
n/a
NameBDBM313347
Synonyms:US10166249, Example 581
TypeSmall organic molecule
Emp. Form.C25H34NO6P
Mol. Mass.475.5143
SMILESN[C@]1(COP(O)(O)=O)CC[C@@H](C1)c1ccc2C[C@@H](CCc2c1)OCCOCc1ccccc1 |r|
Structure
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