Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase JAK1 [866-1154] |
---|
Ligand | BDBM264225 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Inhibition Studies |
---|
IC50 | <3.00±n/a nM |
---|
Citation | Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK1 [866-1154] |
---|
Name: | Tyrosine-protein kinase JAK1 [866-1154] |
Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
Type: | Protein |
Mol. Mass.: | 33185.74 |
Organism: | Homo sapiens (Human) |
Description: | P23458[866-1154] |
Residue: | 289 |
Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
|
|
|
BDBM264225 |
---|
n/a |
---|
Name | BDBM264225 |
Synonyms: | (2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)- 2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 45 | US10654835, Example 45 | US11247983, Example 45 | US9714236, 45 |
Type | Small organic molecule |
Emp. Form. | C27H35N9O3 |
Mol. Mass. | 533.6253 |
SMILES | COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C |r| |
Structure |
|