| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM313654 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Raf Activity Determination |
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| IC50 | 70.0±n/a nM |
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| Citation |  Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Lou, Y; Nishiguchi, GA; Ramurthy, S; Rico, AC; Rauniyar, V; Sendzik, M; Subramanian, S; Setti, LQ; Taft, BR; Tanner, HR; Wan, L Compounds and compositions as RAF kinase inhibitors US Patent US10167279 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 73082.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM313654 |
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| n/a |
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| Name | BDBM313654 |
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| Synonyms: | (R)-2-chloro-N-(3-(2- (2,3- dihydroxypropoxy)-6- (tetrahydro-2H-pyran-4- yl)pyridin-4-yl)-4- methylphenyl) isonicotinamide | US10167279, Example 280 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28ClN3O5 |
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| Mol. Mass. | 497.971 |
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| SMILES | Cc1ccc(NC(=O)c2ccnc(Cl)c2)cc1-c1cc(OC[C@H](O)CO)nc(c1)C1CCOCC1 |r| |
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| Structure | 
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