| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM160781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibitory Activity of Caspase |
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| IC50 | 10.00±n/a nM |
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| Citation |  Ahlfors, J; Mekouar, K Selective caspase inhibitors and uses thereof US Patent US10167313 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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|
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| BDBM160781 |
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| n/a |
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| Name | BDBM160781 |
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| Synonyms: | US10167313, Compound 48 | US9045524, 48 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H40ClN5O11S |
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| Mol. Mass. | 774.237 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc2ccccc2n1)NC(=O)[C@H](CC(O)=O)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)\C=C(/Cl)S(C)(=O)=O |r| |
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| Structure | 
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