| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Ligand | BDBM164395 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDE10A Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.33±n/a nM |
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| Comments | extracted |
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| Citation |  Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent US9669029 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779] |
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| Synonyms: | PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A) |
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| Type: | n/a |
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| Mol. Mass.: | 39060.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y233[440-779] |
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| Residue: | 340 |
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| Sequence: | ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLC
RFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRG
FSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKA
IIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTA
NDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTE
PLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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| BDBM164395 |
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| n/a |
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| Name | BDBM164395 |
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| Synonyms: | US9669029, 98 8-Methoxy-5-methyl-2-{2-[1-(2-morpholin-4-yl-ethyl)-4-thiophen-2-yl-1H-imidazol-2-yl]-ethyl}-[1,2,4]triazolo[1,5-a]pyridine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N6O2S |
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| Mol. Mass. | 454.588 |
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| SMILES | COC1=CC=C(C)N2N=C(CCc3nc(cn3CCN3CCOCC3)-c3cccs3)NC12 |t:2,4,8| |
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| Structure | 
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