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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
LigandBDBM164545
Substrate/Competitorn/a
Meas. Tech.PDE10A Inhibition Assay
Temperature298.15±n/a K
IC50 0.44±n/a nM
Commentsextracted
Citation Püschl, ANielsen, JKehler, JKilburn, JPMarigo, MLanggård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent US9669029 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Name:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:n/a
Mol. Mass.:39060.01
Organism:Homo sapiens (Human)
Description:Q9Y233[440-779]
Residue:340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLC
RFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRG
FSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKA
IIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTA
NDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTE
PLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
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BDBM164545
n/a
NameBDBM164545
Synonyms:US9669029, 116 5,8-Dimethyl-2-[2-(1-methyl-4-pyrimidin-5-yl-1H-imidazol-2-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine
TypeSmall organic molecule
Emp. Form.C17H20N8
Mol. Mass.336.3943
SMILESCC1=CN=C(C)C2NC(CCc3nc(cn3C)-c3cncnc3)=NN12 |c:24,t:1,3|
Structure
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