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TargetAcetylcholinesterase
LigandBDBM10514
Substrate/CompetitorBDBM8959
Meas. Tech.Enzyme Inhibition Assay
pH8±n/a
Temperature310.15±n/a K
IC50 21.5±0.8 nM
Citation Rosini, MAndrisano, VBartolini, MBolognesi, MLHrelia, PMinarini, ATarozzi, AMelchiorre, C Rational approach to discover multipotent anti-Alzheimer drugs. J Med Chem48:360-3 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Acetylcholinesterase
Name:Acetylcholinesterase
Synonyms:ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:Enzyme
Mol. Mass.:67792.70
Organism:Homo sapiens (Human)
Description:P22303
Residue:614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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  Blast E-value cutoff:
BDBM10514
BDBM8959
NameBDBM10514
Synonyms:CHEMBL191758 | N-(3-aminopropyl)-6-chloro-1,2,3,4-tetrahydroacridin-9-amine | N1-(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)propane-1,3-diamine | tacrine (TC) deriv. 15
TypeSmall organic molecule
Emp. Form.C16H20ClN3
Mol. Mass.289.803
SMILESNCCCNc1c2CCCCc2nc2cc(Cl)ccc12
Structure
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