| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM10526 |
|---|
| Substrate/Competitor | BDBM8959 |
|---|
| Meas. Tech. | Measurement of FBSAChE/EqBuChE Inhibitory Activity |
|---|
| pH | 8±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 650±n/a nM |
|---|
| Citation |  Savini, L; Campiani, G; Gaeta, A; Pellerano, C; Fattorusso, C; Chiasserini, L; Fedorko, JM; Saxena, A Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem Lett11:1779-82 (2001) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67792.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22303 |
|---|
| Residue: | 614 |
|---|
| Sequence: | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
|
|
|
|---|
| BDBM10526 |
|---|
| BDBM8959 |
|---|
| Name | BDBM10526 |
|---|
| Synonyms: | N-[4-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)butyl]-1,2,3,4-tetrahydroacridin-9-amine | tacrine heterobivalent compound 3j |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H33N3S |
|---|
| Mol. Mass. | 467.668 |
|---|
| SMILES | C(CCSc1c2CCCCc2nc2ccccc12)CNc1c2CCCCc2nc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
