Reaction Details |
| Report a problem with these data |
Target | Carboxylic ester hydrolase |
---|
Ligand | BDBM10520 |
---|
Substrate/Competitor | BDBM8978 |
---|
Meas. Tech. | Measurement of FBSAChE/EqBuChE Inhibitory Activity |
---|
pH | 8±n/a |
---|
Temperature | 298.15±n/a K |
---|
Ki | 380±n/a nM |
---|
Citation | Savini, L; Campiani, G; Gaeta, A; Pellerano, C; Fattorusso, C; Chiasserini, L; Fedorko, JM; Saxena, A Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem Lett11:1779-82 (2001) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Carboxylic ester hydrolase |
---|
Name: | Carboxylic ester hydrolase |
Synonyms: | BuChE | Butyrlcholinesterase (BuChE) | Butyrylcholine esterase | Butyrylcholinesterase | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | Butyrylcholinesterase (EqBuChE) | Carboxylic ester hydrolase | butyrylcholinesterase precursor |
Type: | Protein |
Mol. Mass.: | 68842.83 |
Organism: | Equus caballus (Horse) |
Description: | Q9N1N9 |
Residue: | 602 |
Sequence: | MQSWGTIICIRILLRFLLLWVLIGNSHTEEDIIITTKNGKVRGMNLPVLGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDC
LYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPR
SQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEI
LLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDV
VGDYNIICPALEFTKKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLER
RVNYTKAEEILSRSIMKRWANFAKYGNPNGTQSNSTRWPVFKSTEQKYLTLNTESPKVYT
KLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCS
DF
|
|
|
BDBM10520 |
---|
BDBM8978 |
---|
Name | BDBM10520 |
Synonyms: | 9-{[7-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)heptyl]sulfanyl}-1,2,3,4-tetrahydroacridine | tacrine homobivalent compound 3d |
Type | Small organic molecule |
Emp. Form. | C33H38N2S2 |
Mol. Mass. | 526.798 |
SMILES | C(CCCSc1c2CCCCc2nc2ccccc12)CCCSc1c2CCCCc2nc2ccccc12 |
Structure |
|