| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-degrading enzyme |
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| Ligand | BDBM314087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Protease Assay |
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| IC50 | 10000±n/a nM |
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| Citation |  Liu, DR; Maianti, JP; Saghatelian, A; Kleiner, RE Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof US Patent US9610322 Publication Date 4/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-degrading enzyme |
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| Name: | Insulin-degrading enzyme |
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| Synonyms: | Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 117968.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14735 |
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| Residue: | 1019 |
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| Sequence: | MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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| BDBM314087 |
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| n/a |
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| Name | BDBM314087 |
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| Synonyms: | US9610322, 2 (cis olefin) |
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| Type | Small organic molecule |
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| Emp. Form. | C43H57N7O7 |
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| Mol. Mass. | 783.9554 |
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| SMILES | NC(=N)NCCC[C@@H]1NC(=O)\C=C\C(=O)NC(CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC1=O)C(N)=O |r,t:11| |
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| Structure | 
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