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TargetMAP kinase-interacting serine/threonine-protein kinase 2
LigandBDBM168372
Substrate/Competitorn/a
Meas. Tech.Mnk Biochemical Enzymatic Assay
Temperature298.15±n/a K
IC50<10.00±n/a nM
Commentsextracted
Citation Reich, SHSprengeler, PAWebber, SEXiang, AXErnst, JT MNK inhibitors and methods related thereto US Patent US9669031 Publication Date 6/6/2017
More Info.:Get all data from this article,  Assay Method
 
MAP kinase-interacting serine/threonine-protein kinase 2
Name:MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:Protein
Mol. Mass.:51870.79
Organism:Homo sapiens (Human)
Description:Q9HBH9
Residue:465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
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BDBM168372
n/a
NameBDBM168372
Synonyms:US9669031, 226 6-((6-aminopyrimidin-4-yl)amino)-1′-(2,2-difluoroethyl)-8-methyl-2H-spiro[imidazo[1,5-a]pyridine-3,4′-piperidine]-1,5-dione (Cpd. No. 226)
TypeSmall organic molecule
Emp. Form.C28H37F2N7O6
Mol. Mass.605.6335
SMILESCc1cc(Nc2cc(ncn2)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(=O)n2c1C(=O)NC21CCN(CC(F)F)CC1
Structure
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