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TargetCaspase-3
LigandBDBM10246
Substrate/CompetitorCaspase Fluorogenic Substrate
Meas. Tech.Caspase Inhibition Assay
pH7±n/a
Temperature310.15±n/a K
IC50 27±n/a nM
Citation Isabel, E; Black, WC; Bayly, CI; Grimm, EL; Janes, MK; McKay, DJ; Nicholson, DW; Rasper, DM; Renaud, J; Roy, S; Tam, J; Thornberry, NA; Vaillancourt, JP; Xanthoudakis, S; Zamboni, R Nicotinyl aspartyl ketones as inhibitors of caspase-3. Bioorg Med Chem Lett13:2137-40 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Caspase-3
Name:Caspase-3
Synonyms:Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:31607.55
Organism:Homo sapiens (Human)
Description:n/a
Residue:277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM10246
Caspase Fluorogenic Substrate
Name:Caspase Fluorogenic Substrate
Synonyms:Ac-DEVD-AMC | Caspase Fluorogenic Substrate
Type:Peptide
Mol. Mass.:1461.77
Organism:n/a
Description:AMC=7-Amino-4-methylcoumarin
Residue:16
Sequence:
Ac-Asp-Glu-Val-Asp-AMC