| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 21-hydroxylase |
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| Ligand | BDBM50435990 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity Assay |
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| IC50 | 248±24 nM |
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| Citation |  Aube, J; Scott, EE; Fehl, C Inhibitors of CYP17A1 US Patent US9611270 Publication Date 4/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 21-hydroxylase |
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| Name: | Steroid 21-hydroxylase |
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| Synonyms: | CP21A_HUMAN | CYP21 | CYP21A2 | CYP21B | Cytochrome P450 21 | Cytochrome P450 21A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55896.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1498865 |
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| Residue: | 494 |
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| Sequence: | MLLLGLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYR
LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAHK
KLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDK
IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ
LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTL
SWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVP
LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALA
FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRL
QPRGMGAHSPGQNQ
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| BDBM50435990 |
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| n/a |
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| Name | BDBM50435990 |
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| Synonyms: | GALETERONE | TOK-001 | US9611270, galaterone | VN/124 | VN/124-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N2O |
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| Mol. Mass. | 388.5451 |
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| SMILES | C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC=C2n1cnc2ccccc12 |r,c:21,t:7| |
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| Structure | 
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