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TargetProtein O-GlcNAcase
LigandBDBM314796
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
Ki 0.590±n/a nM
Citation Selnick, HGLi, WHostetler, ELiu, KMcEachern, EJZhou, YWei, ZMu, CWang, YChang, J Permeable glycosidase inhibitors and uses thereof US Patent US9611275 Publication Date 4/4/2017
More Info.:Get all data from this article,  Assay Method
 
Protein O-GlcNAcase
Name:Protein O-GlcNAcase
Synonyms:2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase
Type:Enzyme
Mol. Mass.:102874.67
Organism:Homo sapiens (Human)
Description:O60502
Residue:916
Sequence:
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
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  Blast E-value cutoff:
BDBM314796
n/a
NameBDBM314796
Synonyms:(3aR,5S,6S,7R,7aR)-2- (methylamino)-5-((R)-2,2,2- trifluoro-1-(4-(3- fluoropropyl)benzyloxy)ethyl)- 5,6,7,7a-tetrahydro-3aH- pyrano[3,2-d]thiazole-6,7-diol | US9611275, Example 88
TypeSmall organic molecule
Emp. Form.C19H24F4N2O4S
Mol. Mass.452.463
SMILESCNC1=N[C@H]2[C@H](O[C@H]([C@@H](OCc3ccc(CCCF)cc3)C(F)(F)F)[C@@H](O)[C@@H]2O)S1 |t:2|
Structure
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