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TargetAcetylcholinesterase
LigandBDBM10726
Substrate/CompetitorBDBM10759
Meas. Tech.Cholinesterase Inhibition Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 30±n/a nM
Citation Sterling, JHerzig, YGoren, TFinkelstein, NLerner, DGoldenberg, WMiskolczi, IMolnar, SRantal, FTamas, TToth, GZagyva, AZekany, AFinberg, JLavian, GGross, AFriedman, RRazin, MHuang, WKrais, BChorev, MYoudim, MBWeinstock, M Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem45:5260-79 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Acetylcholinesterase
Name:Acetylcholinesterase
Synonyms:ACES_HUMAN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase (human AChE)
Type:Enzyme
Mol. Mass.:67792.70
Organism:Homo sapiens (Human)
Description:P22303
Residue:614
Sequence:
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
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BDBM10726
BDBM10759
NameBDBM10726
Synonyms:3-[1-(dimethylamino)ethyl]phenyl N,N-dimethylcarbamate | rivastigmine analog 1a
TypeSmall organic molecule
Emp. Form.C13H20N2O2
Mol. Mass.236.3101
SMILESCC(N(C)C)c1cccc(OC(=O)N(C)C)c1
Structure
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