| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM50043906 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Known Inhibitors of Carbonic Anhydrase |
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| IC50 | 9.00±n/a nM |
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| Citation |  Collier, GR; Walder, KR; Campbell, JA; Molero-Navajas, J; Konstantopoulos, N; Krippner, GY Insulin sensitisers and methods of treatment US Patent US10172837 Publication Date 1/8/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase 1 |
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| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM50043906 |
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| n/a |
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| Name | BDBM50043906 |
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| Synonyms: | CHEMBL269001 | Dorzolamide | MK-507 | US10172837, Dorzolamide |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16N2O4S3 |
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| Mol. Mass. | 324.44 |
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| SMILES | CCNC1CC(C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |
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| Structure | 
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