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TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H]
LigandBDBM279992
Substrate/Competitorn/a
Meas. Tech.In Vitro Assays for IDH1m (R132H or R132C) Inhibitors
IC50<50±n/a nM
Citation Konteatis, ZDPopovici-Muller, JTravins, JMZahler, RCai, ZZhou, D Therapeutically active compounds and their methods of use US Patent US10172864 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Name:Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
Synonyms:Cytosolic NADP-isocitrate dehydrogenase (IDH1)(R132H) | IDH1 | IDH1 R132H | IDH1(R132H) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H) | PICD
Type:Protein
Mol. Mass.:46641.74
Organism:Homo sapiens (Human)
Description:Human IDH1 R132H (SEQ ID No. 2 in patent). First three are removed. Google patent parsed wrong.
Residue:414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM279992
n/a
NameBDBM279992
Synonyms:US10028961, Compound 145 | US10172864, Compound 145 | US10946023, Compound 145
TypeSmall organic molecule
Emp. Form.C17H16F6N6
Mol. Mass.418.3396
SMILESFC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
Structure
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