Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Amine oxidase [flavin-containing] B | ||
| Ligand | BDBM254549 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Monoamine Oxidase Assays | ||
| Ki | 20500±n/a nM | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9670136 Publication Date 6/6/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Amine oxidase [flavin-containing] B | |||
| Name: | Amine oxidase [flavin-containing] B | ||
| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) | ||
| Type: | Protein | ||
| Mol. Mass.: | 58768.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27338 | ||
| Residue: | 520 | ||
| Sequence: |
| ||
| BDBM254549 | |||
| n/a | |||
| Name | BDBM254549 | ||
| Synonyms: | US10214477, Example 8 | US9469597, 8 | US9670136, 8 N1-((trans)-2-(6-(3-(trifluoromethyl)phenyl)pyridin-3-yl)cyclopropyl)cyclohexane-1,4-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24F3N3 | ||
| Mol. Mass. | 375.4306 | ||
| SMILES | NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F |r,wU:10.12,wD:8.8,(8.17,4.84,;6.83,4.07,;6.83,2.53,;5.5,1.76,;4.17,2.53,;4.17,4.07,;5.5,4.84,;2.83,1.76,;1.5,2.53,;.73,3.87,;-.04,2.53,;-1.37,1.76,;-2.71,2.53,;-4.04,1.76,;-4.04,.22,;-2.71,-.55,;-1.37,.22,;-5.37,-.55,;-6.71,.22,;-8.04,-.55,;-8.04,-2.09,;-6.75,-2.94,;-5.37,-2.09,;-6.77,-4.48,;-6.79,-6.02,;-8.31,-4.46,;-5.23,-4.51,)| | ||
| Structure | 
| ||