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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lysine-specific histone demethylase 1A | ||
| Ligand | BDBM254574 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | LSD1 Assays | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 21±n/a nM | ||
| Comments | extracted | ||
| Citation |  Ortega Muñoz, A; Fyfe, MC; Martinell Pedemonte, M; Estiarte Martinez, M; Valls Vidal, N; Kurz, G; Castro Palomino Laria, JC (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors US Patent US9670136 Publication Date 6/6/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lysine-specific histone demethylase 1A | |||
| Name: | Lysine-specific histone demethylase 1A | ||
| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92901.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60341 | ||
| Residue: | 852 | ||
| Sequence: |
| ||
| BDBM254574 | |||
| n/a | |||
| Name | BDBM254574 | ||
| Synonyms: | US10214477, Example 33 | US9469597, 33 | US9670136, 33 N1-(2-(naphthalen-2-yl)cyclopropyl)cyclohexane-1,4-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N2 | ||
| Mol. Mass. | 280.4073 | ||
| SMILES | NC1CCC(CC1)NC1CC1c1ccc2ccccc2c1 |(6.77,3.85,;5.44,3.08,;5.44,1.54,;4.1,.77,;2.77,1.54,;2.77,3.08,;4.1,3.85,;1.44,.77,;.1,1.54,;-.67,2.87,;-1.44,1.54,;-2.77,.77,;-4.1,1.54,;-5.44,.77,;-5.44,-.77,;-6.77,-1.54,;-6.77,-3.08,;-5.44,-3.85,;-4.1,-3.08,;-4.1,-1.54,;-2.77,-.77,)| | ||
| Structure | 
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