| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
|---|
| Ligand | BDBM316174 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescent Polarization Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Örfi, L; Kéri, G 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity US Patent US9617225 Publication Date 4/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 9 |
|---|
| Name: | Cyclin-dependent kinase 9 |
|---|
| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 42789.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 372 |
|---|
| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
|
|
|
|---|
| BDBM316174 |
|---|
| n/a |
|---|
| Name | BDBM316174 |
|---|
| Synonyms: | N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-(4-methylpiperazin-1-yl)phenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine | US10294218, Example 2 | US9617225, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H31N7O |
|---|
| Mol. Mass. | 505.6134 |
|---|
| SMILES | COc1ccccc1-c1cc(Nc2ccc(N3CCN(C)CC3)c(Cn3cnc4ccccc34)c2)ncn1 |
|---|
| Structure | 
|
|---|
Search and Browse
