| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-glucuronidase |
|---|
| Ligand | BDBM316383 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | β-Glucuronidase Activity Assay |
|---|
| IC50 | 290±n/a nM |
|---|
| Citation |  Williams, AL; Scott, J; Yeh, L; Redinbo, MR Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase US Patent US9617239 Publication Date 4/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-glucuronidase |
|---|
| Name: | Beta-glucuronidase |
|---|
| Synonyms: | β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74736.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 651 |
|---|
| Sequence: | MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
|
|
|
|---|
| BDBM316383 |
|---|
| n/a |
|---|
| Name | BDBM316383 |
|---|
| Synonyms: | US9617239, BRITE-354873 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21ClF3N3O3S2 |
|---|
| Mol. Mass. | 531.999 |
|---|
| SMILES | FC(F)(F)c1cccc(CNS(=O)(=O)c2cc(Cl)c(Oc3cccc(c3)N3CCNCC3)s2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
