| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Ligand | BDBM316886 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | LANCE Ultra Assay |
|---|
| IC50 | <500±n/a nM |
|---|
| Citation |  Lee, G; Jeon, HS; Jeon, KJ; Rhim, CY; Kim, JS; Seo, J; Cho, SY; Kim, CS; Lee, JS; Choi, EK; Hwang, JJ; Kim, B Substituted pyridinone compounds as MEK inhibitors US Patent US9617261 Publication Date 4/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2 |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 43439.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates. |
|---|
| Residue: | 393 |
|---|
| Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
|
|
|
|---|
| BDBM316886 |
|---|
| n/a |
|---|
| Name | BDBM316886 |
|---|
| Synonyms: | US9617261, Example 00087 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23FIN3O4 |
|---|
| Mol. Mass. | 515.3172 |
|---|
| SMILES | Cn1c(Nc2ccc(I)cc2F)c(C(=O)NOCCO)c2CC(C)(C)Cc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
