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TargetCarbonic Anhydrase (hpCA)
LigandBDBM10876
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 876±n/a nM
Citation Nishimori IMinakuchi TMorimoto KSano SOnishi STakeuchi HVullo DScozzafava ASupuran CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem 49:2117-26 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic Anhydrase (hpCA)
Name:Carbonic Anhydrase (hpCA)
Synonyms:hpCA
Type:Enzyme
Mol. Mass.:28277.52
Organism:Helicobacter pylori J99
Description:Q9ZK30
Residue:247
Sequence:
MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNLKEVALDAFLPKS
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAETR
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  Blast E-value cutoff:
BDBM10876
BDBM10856
NameBDBM10876
Synonyms:4-(hydroxymethyl)benzene-1-sulfonamide | CHEMBL6919 | JMC522226 Compound 20 | JMC523116 Compound 20 | aromatic/heteroaromatic sulfonamide 21
TypeSmall organic molecule
Emp. Form.C7H9NO3S
Mol. Mass.187.216
SMILESNS(=O)(=O)c1ccc(CO)cc1
Structure
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