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TargetCARBONIC ANHYDRASE
LigandBDBM10900
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 31±n/a nM
Citation Nishimori, IMinakuchi, TMorimoto, KSano, SOnishi, STakeuchi, HVullo, DScozzafava, ASupuran, CT Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. J Med Chem49:2117-26 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
CARBONIC ANHYDRASE
Name:CARBONIC ANHYDRASE
Synonyms:Carbonic Anhydrase (hpCA) | hpCA
Type:Enzyme
Mol. Mass.:28277.52
Organism:Helicobacter pylori J99
Description:Q9ZK30
Residue:247
Sequence:
MKKTFLIALALTASLIGAENTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYY
HTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLIN
NKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNLKEVALDAFLPKS
INYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVII
KSSAETR
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  Blast E-value cutoff:
BDBM10900
BDBM10856
NameBDBM10900
Synonyms:4-(4-tert-Butylphenylsulfonamidomethyl)benzenesulfonamide | 4-[(4-tert-butylbenzene)sulfonamidomethyl]benzene-1-sulfonamide | aromatic/heteroaromatic sulfonamide 34
TypeSmall organic molecule
Emp. Form.C17H22N2O4S2
Mol. Mass.382.498
SMILESCC(C)(C)c1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O
Structure
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