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TargetPhosphodiesterase 9A
LigandBDBM317136
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 1.000±n/a nM
Citation Luo HWan YKe HLiu PHuang MShao YZhu XCai YLiu Y N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof US Patent  US9617269 Publication Date 4/11/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase 9A
Name:3',5'-cyclic phosphodiesterase
Synonyms:High affinity cGMP-specific 3'',5''-cyclic phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (Human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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  Blast E-value cutoff:
BDBM317136
n/a
NameBDBM317136
Synonyms:US9617269, Compound WYQ-87-D | US9617269, Compound WYQ-87-L
TypeSmall organic molecule
Emp. Form.C18H22N6O3
Mol. Mass.370.4057
SMILESCOc1ccc(NC(=O)C(C)Nc2nc3n(ncc3c(=O)[nH]2)C(C)C)cc1
Structure
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