| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Ligand | BDBM317140 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 0.600±n/a nM |
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| Citation |  Luo, H; Wan, Y; Ke, H; Liu, P; Huang, M; Shao, Y; Zhu, X; Cai, Y; Liu, Y N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof US Patent US9617269 Publication Date 4/11/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Name: | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A) |
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| Type: | Protein |
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| Mol. Mass.: | 68488.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O76083 |
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| Residue: | 593 |
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| Sequence: | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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| BDBM317140 |
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| n/a |
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| Name | BDBM317140 |
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| Synonyms: | US9617269, Compound WYQ-90-D |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N6O3 |
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| Mol. Mass. | 398.4588 |
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| SMILES | COc1ccc(NC(=O)C(C)NC2=NC3C(C=NN3C3CCCC3)C(=O)N2)cc1 |c:16,t:12| |
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| Structure | 
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