| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
|---|
| Ligand | BDBM317217 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic TDO Assay |
|---|
| IC50 | 550±n/a nM |
|---|
| Citation |  Kumar, S; Waldo, J; Jaipuri, F; Mautino, M Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization US Patent US9617272 Publication Date 4/11/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 2,3-dioxygenase |
|---|
| Name: | Tryptophan 2,3-dioxygenase |
|---|
| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47874.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_825691 |
|---|
| Residue: | 406 |
|---|
| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
|
|
|
|---|
| BDBM317217 |
|---|
| n/a |
|---|
| Name | BDBM317217 |
|---|
| Synonyms: | US9617272, Compound 101 | US9981973, Compound 101 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H8N2 |
|---|
| Mol. Mass. | 156.1839 |
|---|
| SMILES | C1c2cn[nH]c2-c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
