| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carboxylic ester hydrolase |
|---|
| Ligand | BDBM10441 |
|---|
| Substrate/Competitor | BDBM8978 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 70200±800 nM |
|---|
| Citation |  Feng, S; Wang, Z; He, X; Zheng, S; Xia, Y; Jiang, H; Tang, X; Bai, D Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem48:655-7 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carboxylic ester hydrolase |
|---|
| Name: | Carboxylic ester hydrolase |
|---|
| Synonyms: | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | BuChE | Butyrylcholinesterase (BuChE) | butyrylcholinesterase precursor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67776.22 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 597 |
|---|
| Sequence: | MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPP
LGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNV
WIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFP
GNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLF
TRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEK
LVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGF
SKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYN
IICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYT
RAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAP
QCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
|
|
|
|---|
| BDBM10441 |
|---|
| BDBM8978 |
|---|
| Name | BDBM10441 |
|---|
| Synonyms: | (+)-Huperzine A | (+/-)Huperzine A | (-)-Huperzine A | (13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one | (1R,13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one | (1S,13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,10-trien-5-one | (5S,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one | Huperzine A |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18N2O |
|---|
| Mol. Mass. | 242.3162 |
|---|
| SMILES | C\C=C1/C2Cc3[nH]c(=O)ccc3C1(N)CC(C)=C2 |c:18,TLB:10:11:2:17.15.14,THB:1:2:4.5.11:17.15.14| |
|---|
| Structure | 
|
|---|
Search and Browse
