| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
|---|
| Ligand | BDBM11013 |
|---|
| Substrate/Competitor | BDBM10990 |
|---|
| Meas. Tech. | MAO Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 311.15±n/a K |
|---|
| Ki | 27±0.3 nM |
|---|
| Citation |  Chimenti, F; Maccioni, E; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Befani, O; Turini, P; Alcaro, S; Ortuso, F; Cirilli, R; La Torre, F; Cardia, MC; Distinto, S Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives. J Med Chem48:7113-22 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] A |
|---|
| Name: | Amine oxidase [flavin-containing] A |
|---|
| Synonyms: | AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59764.63 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_1501477 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
|
|
|
|---|
| BDBM11013 |
|---|
| BDBM10990 |
|---|
| Name | BDBM11013 |
|---|
| Synonyms: | 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole deriv. 10 | 3,5-bis(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H11N3S3 |
|---|
| Mol. Mass. | 293.431 |
|---|
| SMILES | NC(=S)N1N=C(CC1c1cccs1)c1cccs1 |c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
