Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAmine oxidase [flavin-containing] B
LigandBDBM11012
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Inhibition Assay
pH7.4±n/a
Temperature311.15±n/a K
Ki 20±0.5 nM
Citation Chimenti, FMaccioni, ESecci, DBolasco, AChimenti, PGranese, ABefani, OTurini, PAlcaro, SOrtuso, FCirilli, RLa Torre, FCardia, MCDistinto, S Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives. J Med Chem48:7113-22 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Amine oxidase [flavin-containing] B
Name:Amine oxidase [flavin-containing] B
Synonyms:AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B
Type:PROTEIN
Mol. Mass.:58428.94
Organism:Bos taurus
Description:ChEMBL_1501478
Residue:520
Sequence:
MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWR
TMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEV
SALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQ
TGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVY
YKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEER
LKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTT
FLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM11012
BDBM10990
NameBDBM11012
Synonyms:1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole deriv. 9 | 5-(furan-2-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
TypeSmall organic molecule
Emp. Form.C12H11N3OS2
Mol. Mass.277.365
SMILESNC(=S)N1N=C(CC1c1ccco1)c1cccs1 |c:4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: