Reaction Details |
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Target | Amine oxidase [flavin-containing] B |
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Ligand | BDBM11012 |
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Substrate/Competitor | BDBM10990 |
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Meas. Tech. | MAO Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 311.15±n/a K |
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Ki | 20±0.5 nM |
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Citation | Chimenti, F; Maccioni, E; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Befani, O; Turini, P; Alcaro, S; Ortuso, F; Cirilli, R; La Torre, F; Cardia, MC; Distinto, S Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives. J Med Chem48:7113-22 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Amine oxidase [flavin-containing] B |
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Name: | Amine oxidase [flavin-containing] B |
Synonyms: | AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B |
Type: | PROTEIN |
Mol. Mass.: | 58428.94 |
Organism: | Bos taurus |
Description: | ChEMBL_1501478 |
Residue: | 520 |
Sequence: | MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWR
TMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEV
SALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQ
TGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVY
YKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEER
LKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTT
FLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
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BDBM11012 |
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BDBM10990 |
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Name | BDBM11012 |
Synonyms: | 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole deriv. 9 | 5-(furan-2-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide |
Type | Small organic molecule |
Emp. Form. | C12H11N3OS2 |
Mol. Mass. | 277.365 |
SMILES | NC(=S)N1N=C(CC1c1ccco1)c1cccs1 |c:4| |
Structure |
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