Reaction Details |
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Target | Amine oxidase |
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Ligand | BDBM11018 |
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Substrate/Competitor | BDBM11019 |
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Meas. Tech. | MAO Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | >1000000±n/a nM |
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Comments | no inhibition |
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Citation | Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem280:15761-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Amine oxidase |
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Name: | Amine oxidase |
Synonyms: | Amine oxidase (flavin-containing) B | MAO-B | Monoamine Oxidase Type B (MAO-B) |
Type: | Enzyme |
Mol. Mass.: | 50985.83 |
Organism: | Ovis aries (sheep) |
Description: | Mitochondrial preparation. |
Residue: | 451 |
Sequence: | RIHILTSDSGLQINQKNINSCISQGKSYPFRGSFPSVWNPIAYLDHNNLWRTMDDMGREI
PSDAPWKAPLAEQWDRMTMKELLDKICWTESSKQLAILFVNLCVSAEIHEVSALWFLWYV
KQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMELLGDRVKLERPVIHIDQTGENVLVET
LNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNM
DYCGSMIIEGEEAPVAYTLDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYA
KVLGSQEALHPVHYEEKNWCEEQYSAGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETA
THWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSV
PGLLKLIGLTTIISATALGYLAHKRGLLVRI
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BDBM11018 |
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BDBM11019 |
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Name | BDBM11018 |
Synonyms: | 2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-3H,4H,5H,6H,7H-imidazo[4,5-c]pyridine-4,6-dione | 8-(3-chlorostyryl)caffeine (CSC) |
Type | Small organic molecule |
Emp. Form. | C17H16ClN3O2 |
Mol. Mass. | 329.781 |
SMILES | CC1c2nc(\C=C\c3cccc(Cl)c3)n(C)c2C(=O)N(C)C1=O |
Structure |
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