Ki Summary

Reaction Details

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Target

Amine oxidase [flavin-containing] B [I199F]

Ligand

BDBM10989

Substrate/Competitor

BDBM10999

Meas. Tech.

MAO Inhibition Assay

500±n/a nM

Citation

Hubalek, F; Binda, C; Khalil, A; Li, M; Mattevi, A; Castagnoli, N; Edmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem280:15761-6 (2005) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Amine oxidase [flavin-containing] B [I199F]

Name:

Amine oxidase [flavin-containing] B [I199F]

Synonyms:

AOFB_HUMAN | Amine oxidase (flavin-containing) B | MAOB | Monoamine Oxidase Type B (MAO-B) Mutant (I199F)

Type:

Enzyme

Mol. Mass.:

58802.78

Organism:

Homo sapiens (Human)

Description:

Human recombinant MAO B were expressed and purified from Pichia pastoris.

Residue:

520

Sequence:

MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

BDBM10989

BDBM10999

Name

BDBM10989

Synonyms:

(1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine | CHEMBL887 | Rasagiline | US9034303, Rasagiline

Type

Small organic molecule

Emp. Form.

C12H13N

Mol. Mass.

171.2383

SMILES

C#CCN[C@@H]1CCc2ccccc12 |r|

Structure