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TargetCarbonic anhydrase 2
LigandBDBM11045
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 8.9±n/a nM
Citation De Simone, GVitale, RMDi Fiore, APedone, CScozzafava, AMontero, JLWinum, JYSupuran, CT Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem49:5544-51 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic anhydrase 2
Name:Carbonic anhydrase 2
Synonyms:CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:Enzyme
Mol. Mass.:29250.71
Organism:Homo sapiens (Human)
Description:P00918
Residue:260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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  Blast E-value cutoff:
BDBM11045
BDBM10856
NameBDBM11045
Synonyms:N-(2-chloro-4-sulfamoylphenyl)-3-sulfanylpropanamide | reduced monomeric thio of compound 2c | reduced thio H2c
TypeSmall organic molecule
Emp. Form.C9H11ClN2O3S2
Mol. Mass.294.778
SMILESNS(=O)(=O)c1ccc(NC(=O)CCS)c(Cl)c1
Structure
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