| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Ligand | BDBM318832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Chen, X; Lan, R; Jorand-Lebrun, C; Yu, H; Goutopoulos, A Pyridazinone macrocycles as IRAK inhibitors and uses thereof US Patent US9624246 Publication Date 4/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Name: | Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Synonyms: | IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55943.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 194-712 |
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| Residue: | 519 |
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| Sequence: | RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM318832 |
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| n/a |
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| Name | BDBM318832 |
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| Synonyms: | US10517872, Compound 9 | US9624246, Compound 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25N7O5 |
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| Mol. Mass. | 479.4885 |
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| SMILES | O=C1NCCCOc2ccc(=O)n(Cc3cccc(n3)C(=O)Nc3cn(nc13)C1CCOCC1)n2 |
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| Structure | 
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