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TargetInterleukin-1 receptor-associated kinase 1 [194-712]
LigandBDBM318835
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50<100±n/a nM
Citation Chen, XLan, RJorand-Lebrun, CYu, HGoutopoulos, A Pyridazinone macrocycles as IRAK inhibitors and uses thereof US Patent US9624246 Publication Date 4/18/2017
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 1 [194-712]
Name:Interleukin-1 receptor-associated kinase 1 [194-712]
Synonyms:IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:55943.99
Organism:Homo sapiens (Human)
Description:aa 194-712
Residue:519
Sequence:
RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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  Blast E-value cutoff:
BDBM318835
n/a
NameBDBM318835
Synonyms:US10517872, Compound 12 | US9624246, Compound 12
TypeSmall organic molecule
Emp. Form.C20H20N6O5
Mol. Mass.424.41
SMILESCn1cc2NC(=O)c3cccc(Cn4nc(OCC(O)CNC(=O)c2n1)ccc4=O)c3
Structure
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