| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
|---|
| Ligand | BDBM11092 |
|---|
| Substrate/Competitor | BDBM11057 |
|---|
| Meas. Tech. | DPPIV Inhibition Assay |
|---|
| Ki | 2.5±n/a nM |
|---|
| Citation |  Pei, Z; Li, X; Longenecker, K; von Geldern, TW; Wiedeman, PE; Lubben, TH; Zinker, BA; Stewart, K; Ballaron, SJ; Stashko, MA; Mika, AK; Beno, DW; Long, M; Wells, H; Kempf-Grote, AJ; Madar, DJ; McDermott, TS; Bhagavatula, L; Fickes, MG; Pireh, D; Solomon, LR; Lake, MR; Edalji, R; Fry, EH; Sham, HL; Trevillyan, JM Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors. J Med Chem49:3520-35 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Dipeptidyl peptidase 4 |
|---|
| Name: | Dipeptidyl peptidase 4 |
|---|
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 88271.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27487 |
|---|
| Residue: | 766 |
|---|
| Sequence: | MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
|
|
|
|---|
| BDBM11092 |
|---|
| BDBM11057 |
|---|
| Name | BDBM11092 |
|---|
| Synonyms: | (2S)-1-{[(2S,5R)-5-[(naphthalen-1-yloxy)methyl]pyrrolidin-2-yl]carbonyl}pyrrolidine-2-carbonitrile | 2-cyanopyrrolidine 21p |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N3O2 |
|---|
| Mol. Mass. | 349.4262 |
|---|
| SMILES | O=C([C@@H]1CC[C@H](COc2cccc3ccccc23)N1)N1CCC[C@H]1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
