| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
|---|
| Ligand | BDBM50329427 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay of Cdc7 Activity |
|---|
| IC50 | <1000±n/a nM |
|---|
| Citation |  Vanotti, E; Caldarelli, M; Cirla, A; Forte, B; Ermoli, A; Menichincheri, M; Pillan, A; Scolaro, A Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene- and furane-derivatives as kinase inhibitors US Patent US9670191 Publication Date 6/6/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
|---|
| Name: | Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A |
|---|
| Synonyms: | Cdc7 Kinase | Cdc7/DBF4 |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cell division cycle 7-related protein kinase [58-574] |
|---|
| Synonyms: | CDC7 | CDC7L1 | CDC7_HUMAN | Cdc7 Kinase | Cell division cycle 7-related protein kinase |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 57470.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00311[58-574] |
|---|
| Residue: | 517 |
|---|
| Sequence: | FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV
MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRD
VKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIP
LSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSS
ISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATD
KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA
SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTS
DIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNE
VPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
|
|
|
|---|
| Component 2 |
| Name: | Protein DBF4 homolog A |
|---|
| Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 |
|---|
| Type: | Regulatory subunit |
|---|
| Mol. Mass.: | 76869.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 674 |
|---|
| Sequence: | MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
|
|
|
|---|
| BDBM50329427 |
|---|
| n/a |
|---|
| Name | BDBM50329427 |
|---|
| Synonyms: | 5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide | CHEMBL1270230 | US9670191, U1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13N5O |
|---|
| Mol. Mass. | 279.2966 |
|---|
| SMILES | NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
